Abstract
Despite the recent advances in the diagnostic and therapeutic armamentarium, the bacterial endocarditis remains one of the most challenging clinical endocarditis remains one of the most challenging clinical problems. The conventional diagnostic methods for bacterial endocarditis often either fail or delay in the diagnosis and treatment of this disease. A new diagnostic test for the bacterial endocarditis is urgently needed in order to initiate the antibiotic therapy promptly. We have found the NBT test [PARK et al., Lancet ii: 532, 1968] to be a useful diagnostic aid in these clinical situations. Patients with proven bacterial endocarditis and those with presenting symptoms suggestive of bacterial endocarditis were studied with the NBT test. The results were compared with those of controls. The absolute number and percentage of the NBT positive neutrophils were found to be regularly increased in seventeen patients with bacterial endocarditis (means: 3,150/mm3, 24.5%) as compared with normal control and patients with non-bacterial disease (439±187/mm3, 6.86±2.87%). Furthermore, the clinical response to the antibiotics therapy was well correlated with the results of the NBT test. The simplicity and instant results are other advantages of NBT test as a diagnostic aid in bacterial endocarditis.
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Park, B., South, M., Barrett, F. et al. The Use of the Nitroblue Tetrazolium Reduction (NBT) Test in Diagnosis and Treatment of Bacterial Endocarditis. Pediatr Res 4, 463 (1970). https://doi.org/10.1203/00006450-197009000-00115
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DOI: https://doi.org/10.1203/00006450-197009000-00115
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