Abstract
It has been reported that susceptible children were protected against varicella if they received two ml of zoster immune globulin (ZIG) within 72 h following household exposure. In a double blind study to determine the minimum modifying dose of ZIG, 0.5 ml of either ZIG or immune serum globulin (ISG) was given to exposed household contacts. It was found that the four children who received ISG developed 161, 285, 286 and 407 vesicles while the children who received ZIG had 0, 2, 4 and 4 vecisles. All seven children who developed vesicles had rises in complement-fixing (CF) antibody. The ZIG which was used in these studies was prepared from plasma of pretested convalescent zoster donors who had CF antibody titers of 1:256 or greater. Pretesting of donors was eliminated subsequently in order to expedite the production of ZIG. Although plasma was obtained when highest antibody titers were expected, only 20 of 35 plasma collections had CF titers high enough (≥1:128) to be used for zIG preparation. The dose of this and subsequent lots of ZIG will bee stimated by comparing their antibody content with that of the reference lot for which the minimum protective dose was determined in thesestudies.
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Brunell, P., Ross, A., Miller, L. et al. Zoster Immune Globulin. Pediatr Res 4, 462 (1970). https://doi.org/10.1203/00006450-197009000-00112
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DOI: https://doi.org/10.1203/00006450-197009000-00112