Abstract
We have treated 58 idiopathic (IH) and 16 organic hypopituitary (OH) children for 12 months, using 5 treatment regiments, in order to determine optimum therapy with HGH and glucocorticoids. All patients had: growth hormone levels < 5 mμg/ml plasma during insulin induced hypoglycemia; bone ages of 12 years or less; sexual infantilism. In IH, height wa −4 SD or further below the mean. In OH, pretreatment growth rate was below 2.5 cm/year. Listed are 5 treatment regimens and growth rates during therapy.
Conclusions: HGH stimulated linear growth of hypopituitary children to varying degrees; more effectively in younger smaller dwarfs, less effectively in the older larger or cortisone treated dwarfs. HGH from embalmed bodies is clinically useful. HGH, 10 U., was not more beneficial than 2 U. The craniopharyngiomas in the OH did not grow during short-term treatment with HGH.
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Aceto, T., Hayles, A., Parker, M. et al. Effects of Human Growth Hormone (HGH) on 79 Hypopituitary Children. Pediatr Res 4, 459–460 (1970). https://doi.org/10.1203/00006450-197009000-00101
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DOI: https://doi.org/10.1203/00006450-197009000-00101