Abstract
Homozygous, jaundiced, Gunn rats (jj) were compared with heterozygous control rats (jJ) for their capacity to concentrate their urine after water deprivation. Animals of comparable weights (5 jj and 6 jJ) were pair fed 7 days and then subjected to a 36-hour fast and thirst. Urine was collected for the last 6 hours, and the mean flow rates were 50 and 149 μl/100 g/h in the jJ and jj animals, respectively. The corresponding urine milli-osmolalities were 1909 and 815. Total solute loads excreted were comparable but the jj animals lost 3 times as much Na in the urine, and had a 30 % greater loss of body weight. Glomerular filtration rates were similar in hydrated jj and jJ animals. The concentrations of Na, K, Cl, NH3 and urea in the renal cortex were similar in the two groups of animals. The concentrations of K and NH3 of the medulla were also similar, but the concentrations of Na, Cl and urea in the medulla of the jj animals were only 1/3 that found in the jJ animals.
Regional analysis of the kidney for bilirubin demonstrated a 100 fold greater concentration in the renal medulla than in the corresponding cortex in jj animals. These results suggest that bilirubin may interfere with sodium and urea reabsorption in the medullary portions of the kidney and therby prevents the formation of hypertonic urine during thirsting comparable to normal rats. (SPR)
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Odell, G., Natzschka, J. & Bruce Storey, G. 50 Bilirubin Nephropathy in the Gunn Rat. Pediatr Res 1, 213 (1967). https://doi.org/10.1203/00006450-196705000-00057
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DOI: https://doi.org/10.1203/00006450-196705000-00057