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Clinical Research

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Prostate Cancer and Prostatic Diseases volume 14, pages 232–237 (2011)Cite this article

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Abstract

To study the staging accuracy of multiparametric magnetic resonance imaging (MRI) in patients showing unilateral low-risk cancer on prostate biopsy. A total of 58 consecutive patients with low-risk cancer (D'Amico classification) and unilateral cancer involvement on prostate biopsies were included prospectively. All patients underwent multiparametric endorectal MRI before radical prostatectomy, including T2-weighted (T2W), diffusion-weighted (DW) and dynamic contrast enhanced (DCE) sequences. Each gland was divided in eight octants. Tumor foci >0.2 cm3 identified on pathological analysis were matched with MRI findings. Pathological examination showed tumor foci >0.2 cm3 in 50/58 glands (86%), and bilateral tumor (pathological stage⩾pT2c) in 20/58 (34%). For tumor detection in the peripheral zone (PZ), T2W+DWI+DCE performed significantly better than T2W+DWI and T2W alone (P<0.001). In the transition zone (TZ), only T2W+DWI performed better than T2W alone (P=0.02). With optimal MR combinations, tumor size was correctly estimated in 77% of tumor foci involving more than one octant. Bilateral tumors were detected in 80% (16/20) of cases. In patients with unilateral low-risk prostate cancer on biopsy, multiparametric MRI can help to predict bilateral involvement. Multiparametric MRI may therefore have a prognostic value and help to determine optimal treatment in such patients.

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Authors and Affiliations

  1. Department of Urology, Cochin Hospital, Paris Descartes University, Paris, France

    N B Delongchamps, T Flam, M Zerbib & M Peyromaure

  2. Department of Pathology, Cochin Hospital, Paris Descartes University, Paris, France

    F Beuvon

  3. Department of Radiology, IRM Paris 16, Paris, France

    D Eiss & F Cornud

  4. iCAD Inc, Nashua, NH, USA

    N Muradyan

  5. Department of Radiology, Cochin Hospital, Paris Descartes University, Paris, France

    F Cornud

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  1. N B Delongchamps
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Correspondence to N B Delongchamps.

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N Muradyan is employed by iCAD. No financial disclosure from any authors.

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Delongchamps, N., Beuvon, F., Eiss, D. et al. Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer. Prostate Cancer Prostatic Dis 14, 232–237 (2011). https://doi.org/10.1038/pcan.2011.9

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