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Clinical Research

Preoperative weight change and risk of adverse outcome following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database

Prostate Cancer and Prostatic Diseases volume 14, pages 361–366 (2011)Cite this article

Subjects

Abstract

Background:

We examined the relationship between weight change in the year before radical prostatectomy (RP) and biochemical recurrence (BCR) and adverse pathology.

Methods:

We abstracted data from 359 men undergoing RP in the SEARCH (Shared Equal Access Regional Cancer Hospital) database between 2001–2007. Logistic regression and Cox proportional hazards models were used to test the association between weight change in the year before surgery and adverse pathology and BCR, respectively.

Results:

In all, 152 (42%) men gained weight, 193 (54%) lost weight and 14 (4%) had the same weight. Among weight gainers, median gain was 2.4 kg and among weight losers, median loss was 2.7 kg. As a continuous variable, weight change was not associated with adverse pathology or BCR (all P>0.05). In secondary analysis, on multivariate analysis, men gaining ⩾2.5 kg were at higher BCR risk (hazards ratio=1.65, 95% confidence interval (CI): 1.03–2.64, P=0.04) while weight loss ⩾2.5 kg was not associated with BCR (hazards ratio=0.83, 95% CI: 0.54–1.29, P=0.41).

Conclusions:

As a continuous variable, weight change was not associated with outcome. In secondary hypothesis-generating analyses, weight gain ⩾2.5 kg in the year before surgery, regardless of final body mass index, was associated with increased BCR following RP. If validated, these data suggest weight gain ⩾2.5 kg may promote prostate cancer progression.

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Authors and Affiliations

  1. Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA

    B M Whitley, D M Moreira, J-A Thomas & S J Freedland

  2. Department of Surgery, Urology Section, Veterans Affairs Medical Center, Durham, NC, USA

    B M Whitley, D M Moreira, J-A Thomas & S J Freedland

  3. Department of Surgery, Urology Section, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA

    W J Aronson

  4. Department of Urology, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA

    W J Aronson

  5. Department of Surgery, Urology Section, Veterans Affairs Medical Center, Augusta, GA, USA

    M K Terris

  6. Division of Urologic Surgery, Department of Surgery, Medical College of Georgia, Augusta, GA, USA

    M K Terris

  7. Department of Urology, Stanford University School of Medicine, Palo Alto, CA, USA

    J C Presti Jr

  8. Department of Surgery, Urology Section, Veterans Affairs Medical Center, Palo Alto, CA, USA

    J C Presti Jr

  9. Division of Urology, Department of Surgery, University of California at San Diego Medical Center, San Diego, CA, USA

    C J Kane

  10. Division of Urology, Department of Surgery, Oregon Health and Science University, Portland, OR, USA

    C L Amling

  11. Department of Pathology, Duke University School of Medicine, Durham, NC, USA

    S J Freedland

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  1. B M Whitley
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the SEARCH Database Study Group

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Correspondence to S J Freedland.

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Whitley, B., Moreira, D., Thomas, JA. et al. Preoperative weight change and risk of adverse outcome following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database. Prostate Cancer Prostatic Dis 14, 361–366 (2011). https://doi.org/10.1038/pcan.2011.42

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  • DOI: https://doi.org/10.1038/pcan.2011.42

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