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Basic Research

XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis

Prostate Cancer and Prostatic Diseases volume 14, pages 225–231 (2011)Cite this article

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Abstract

Epidemiological studies have evaluated the association between X-ray repair cross-complementing group 1 gene (XRCC1) Arg399Gln and Arg194Trp polymorphisms and risk of prostate cancer (PCa). However, the results from the published studies on the association between these two XRCC1 polymorphisms and PCa risk are conflicting. To derive a more precise estimation of association between the XRCC1 polymorphisms and risk of PCa, we performed a meta-analysis. A comprehensive search was conducted to identify all case–control studies of XRCC1 polymorphisms and PCa risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, we found that both Arg399Gln and Arg194Trp polymorphisms were not significantly associated with PCa risk. However, in stratified analysis by ethnicity, we found that the Arg399Gln polymorphism was significantly associated with PCa risk in Asian population (Gln/Gln vs Arg/Arg: OR=1.46, 95% CI: 1.05–2.03, P=0.03; Gln/Gln vs Arg/Gln+Arg/Arg: OR=1.48, 95% CI: 1.12–1.95, P=0.01). In this meta-analysis, we found that both Arg399Gln and Arg194Trp polymorphisms were not related to overall PCa risk. However, in subgroup analysis we found a suggestion that XRCC1 399Gln allele might be a low-penetrent risk factor for PCa only in Asian men.

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Acknowledgements

This work benefited from the helpful comments of two anonymous reviewers.

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  1. B Wei and Y Zhou: These authors contributed equally to this work and should be considered as co-first authors.

Authors and Affiliations

  1. Department of Urology, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China

    B Wei, Z Xu, J Ruan, M Zhu, K Jin, D Zhou, Q Hu, Q Wang, Z Wang & Z Yan

  2. Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki, Finland

    Y Zhou

  3. Faculty of Medicine, University of Helsinki, Helsinki, Finland

    Y Zhou

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Wei, B., Zhou, Y., Xu, Z. et al. XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis. Prostate Cancer Prostatic Dis 14, 225–231 (2011). https://doi.org/10.1038/pcan.2011.26

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