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8q24 allelic imbalance and MYC gene copy number in primary prostate cancer

Prostate Cancer and Prostatic Diseases volume 13, pages 238–243 (2010)Cite this article

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Abstract

Four independent regions within 8q24 near the MYC gene are associated with risk for prostate cancer (Pca). Here, we investigated allelic imbalance (AI) at 8q24 risk variants and MYC gene DNA copy number (CN) in 27 primary Pcas. Heterozygotes were observed in 24 of 27 patients at one or more 8q24 markers and 27% of the loci exhibited AI in tumor DNA. The 8q24 risk alleles were preferentially favored in the tumors. Increased MYC gene CN was observed in 33% of tumors, and the co-existence of increased MYC gene CN with AI at risk loci was observed in 86% (P<0.004 exact binomial test) of the informative tumors. No AI was observed in tumors, which did not reveal increased MYC gene CN. Higher Gleason score was associated with tumors exhibiting AI (P=0.04) and also with increased MYC gene CN (P=0.02). Our results suggest that AI at 8q24 and increased MYC gene CN may both be related to high Gleason score in Pca. Our findings also suggest that these two somatic alterations may be due to the same preferential chromosomal duplication event during prostate tumorigenesis.

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Acknowledgements

We thank all the men who volunteered to participate in this genetic study. This research was funded in part by the Department of Defense (DAMD W81XWH-07-1-0203 and DAMD W81XWH-06-1-0066).

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Authors and Affiliations

  1. Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA

    H Chen, S Hooker & R A Kittles

  2. Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA

    W Liu

  3. James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institutions, Baltimore, MD, USA

    W Roberts & W Isaacs

  4. Department of Pathology, Johns Hopkins Hospital and Medical Institutions, Baltimore, MD, USA

    H Fedor & A DeMarzo

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  1. H Chen
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Correspondence to R A Kittles.

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Chen, H., Liu, W., Roberts, W. et al. 8q24 allelic imbalance and MYC gene copy number in primary prostate cancer. Prostate Cancer Prostatic Dis 13, 238–243 (2010). https://doi.org/10.1038/pcan.2010.20

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