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STRIPAK complexes in cell signaling and cancer

Oncogene volume 35, pages 4549–4557 (2016)Cite this article

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Abstract

Striatin-interacting phosphatase and kinase (STRIPAK) complexes are striatin-centered multicomponent supramolecular structures containing both kinases and phosphatases. STRIPAK complexes are evolutionarily conserved and have critical roles in protein (de)phosphorylation. Recent studies indicate that STRIPAK complexes are emerging mediators and regulators of multiple vital signaling pathways including Hippo, MAPK (mitogen-activated protein kinase), nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are extensively involved in a variety of fundamental biological processes ranging from cell growth, differentiation, proliferation and apoptosis to metabolism, immune regulation and tumorigenesis. Growing evidence correlates dysregulation of STRIPAK complexes with human diseases including cancer. In this review, we summarize the current understanding of the assembly and functions of STRIPAK complexes, with a special focus on cell signaling and cancer.

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Acknowledgements

This work was supported by the 973 Program of the Ministry of Science and Technology of China (2012CB910204), the National Natural Science Foundation of China (31270808, 31300734, 31470736, 31470868, 91442125, 91542125), the Science and Technology Commission of Shanghai Municipality (13ZR1446400) and the ‘Cross and Cooperation in Science and Technology Innovation Team’ project of the Chinese Academy of Sciences, and the Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (2014KIP202).

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  1. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    Z Shi, S Jiao & Z Zhou

  2. School of Life Sciences and Technology, Tongji University, Shanghai, China

    Z Shi

  3. School of Life Science and Technology, ShanghaiTech University, Shanghai, China

    Z Zhou

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Shi, Z., Jiao, S. & Zhou, Z. STRIPAK complexes in cell signaling and cancer. Oncogene 35, 4549–4557 (2016). https://doi.org/10.1038/onc.2016.9

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