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Emerging roles for the non-canonical IKKs in cancer

Oncogene volume 30, pages 631–641 (2011)Cite this article

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Abstract

The IκB Kinase (IKK)-related kinases TBK1 and IKKɛ have essential roles as regulators of innate immunity by modulating interferon and NF-κB signaling. Recent work has also implicated these non-canonical IKKs in malignant transformation. IKKɛ is amplified in ∼30% of breast cancers and transforms cells through the activation of NF-κB. TBK1 participates in RalB-mediated inflammatory responses and cell survival, and is essential for the survival of non-small cell lung cancers driven by oncogenic KRAS. The delineation of target substrates and downstream activities for TBK1 and IKKɛ has begun to define their role(s) in promoting tumorigenesis. In this review, we will highlight the mechanisms by which IKKɛ and TBK1 orchestrate pathways involved in inflammation and cancer.

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Acknowledgements

We thank the members of the Hahn laboratory for advice. This work was supported in part by the US NIH (R01 CA130988).

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Authors and Affiliations

  1. Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA

    R R Shen & W C Hahn

  2. Broad Institute of Harvard and MIT, Cambridge, MA, USA

    W C Hahn

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  1. R R Shen
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  2. W C Hahn
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Correspondence to W C Hahn.

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Shen, R., Hahn, W. Emerging roles for the non-canonical IKKs in cancer. Oncogene 30, 631–641 (2011). https://doi.org/10.1038/onc.2010.493

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  • DOI: https://doi.org/10.1038/onc.2010.493

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