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Serine/threonine phosphatases in the DNA damage response and cancer

Oncogene volume 29, pages 5977–5988 (2010)Cite this article

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Abstract

The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests that these kinases and their substrates are under tight modulation by numerous Ser/Thr phosphatases. In this study, we review recent reports that reveal new functions and regulation of these phosphatases. Similar to the kinases in this pathway, phosphatases may also be intimately involved in cancer progression and present valuable targets for cancer therapy.

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Acknowledgements

We thank members of the Maller lab for stimulating discussions. This work was supported by the Howard Hughes Medical Institute. We apologize to colleagues whose relevant works are not cited here due to space limitations.

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  1. A Peng

    Present address: 2Current address: Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA.,

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  1. Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA

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Peng, A., Maller, J. Serine/threonine phosphatases in the DNA damage response and cancer. Oncogene 29, 5977–5988 (2010). https://doi.org/10.1038/onc.2010.371

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