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The Rafts of the Medusa: cholesterol targeting in cancer therapy

Oncogene volume 29, pages 3745–3747 (2010)Cite this article

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Abstract

In this issue of Oncogene, Mollinedo and co-workers present promising evidence that cholesterol-sensitive signaling pathways involving lipid rafts can be therapeutically targeted in multiple myeloma. Because the pathways considered in their study are used by other types of tumor cells, one implication of this report is that cholesterol-targeting approaches may be applicable to other malignancies.

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Authors and Affiliations

  1. Urological Diseases Research Center, Children's Hospital Boston, Boston, MA, USA

    M R Freeman, D Di Vizio & K R Solomon

  2. Department of Urology, Children's Hospital Boston–Harvard Medical School, Boston, MA, USA

    M R Freeman, D Di Vizio & K R Solomon

  3. Department of Surgery, Children's Hospital Boston–Harvard Medical School, Boston, MA, USA

    M R Freeman & D Di Vizio

  4. Department of Biological Chemistry and Molecular Pharmacology, Children's Hospital Boston–Harvard Medical School, Boston, MA, USA

    M R Freeman

  5. Department of Orthopaedic Surgery, Children's Hospital Boston–Harvard Medical School, Boston, MA, USA

    K R Solomon

Authors
  1. M R Freeman
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  2. D Di Vizio
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  3. K R Solomon
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Correspondence to M R Freeman.

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Freeman, M., Di Vizio, D. & Solomon, K. The Rafts of the Medusa: cholesterol targeting in cancer therapy. Oncogene 29, 3745–3747 (2010). https://doi.org/10.1038/onc.2010.132

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