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Actin and myosin I in the nucleus: what next?

Nature Structural & Molecular Biology volume 12, pages 742–746 (2005)Cite this article

Abstract

Several recent publications have demonstrated the importance of nuclear actin and nuclear myosin I in transcription. Here we review these publications and their implications. In addition, we discuss some important issues that should be addressed to gain a more comprehensive understanding of how these traditionally 'cytoplasmic' proteins are involved in transcription. We propose highly speculative models and mechanisms solely to stimulate thought and experimentation in this area.

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Figure 1: Schematic showing the possible involvement of β-actin and NMI in the various stages of transcription.
Figure 2: NMI binding to DNA.

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Acknowledgements

This work was supported in part by grants from the US National Institutes of Health (GM59648) and the US National Science Foundation (INT 9724168 and MCB 0517468) to P. de L.

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  1. Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, 60612, Illinois, USA

    Primal de Lanerolle, Terazina Johnson & Wilma A Hofmann

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  1. Primal de Lanerolle
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Correspondence to Primal de Lanerolle.

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de Lanerolle, P., Johnson, T. & Hofmann, W. Actin and myosin I in the nucleus: what next?. Nat Struct Mol Biol 12, 742–746 (2005). https://doi.org/10.1038/nsmb983

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