A recent study broadens the substrate profile of the COMPASS histone methyltransferase complex to include a kinetochore component and links the lysine methylation activity of COMPASS to the process of chromosome segregation.
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Acknowledgements
The authors would like to thank E. Torno for assistance in the preparation of this manuscript. Work in the laboratory of A.S. is supported in part by US National Institutes of Health grants 2R01CA089455 and 1R01GM069905 and by the American Cancer Society. A.S. is a Scholar of the Leukemia and Lymphoma Society.
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Wood, A., Shilatifard, A. Guided by COMPASS on a journey through chromosome segregation. Nat Struct Mol Biol 12, 839–840 (2005). https://doi.org/10.1038/nsmb1005-839
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DOI: https://doi.org/10.1038/nsmb1005-839
