The human Kv1.1 potassium channel undergoes RNA editing in its pore domain. Editing replaces an isoleucine with a valine that results in rapid recovery from fast inactivation.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system
Molecular Brain Open Access 29 May 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Bhalla T, Rosenthal, J.J.C., Holmgren, M. & Reenan, R. Nat. Struct. Mol. Biol. 11, 950–956 (2004).
Higuchi, M. et al. Cell 75, 1361–1370 (1993).
Herb, A., Higuchi, M., Sprengel, R. & Seeburg, P. Proc. Natl. Acad. Sci. USA 93, 1875–1880 (1996).
Burns, C. et al. Nature 387, 303–308 (1997).
Doyle, D. et al. Science 280, 69–77 (1998).
Liu, Y., Holmgren, M., Jurman, M. & Yellen, G. Neuron 19, 175–84 (1997).
Zhou, M., Morais-Cabral, J., Mann, S. & MacKinnon, R. Nature 411, 657–661 (2001).
Hoopengardner, B., Bhalla, T., Staber, C. & Reenan, R. Science 301, 832–836 (2003).
Patton, D., Silva, T. & Bezanilla, F. Neuron 19, 711–722 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bezanilla, F. RNA editing of a human potassium channel modifies its inactivation. Nat Struct Mol Biol 11, 915–916 (2004). https://doi.org/10.1038/nsmb1004-915
Issue Date:
DOI: https://doi.org/10.1038/nsmb1004-915