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RNA editing of a human potassium channel modifies its inactivation

The human Kv1.1 potassium channel undergoes RNA editing in its pore domain. Editing replaces an isoleucine with a valine that results in rapid recovery from fast inactivation.

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Figure 1: Schematic representation of a voltage-dependent potassium channel that undergoes fast inactivation indicating the three major states of the channel: closed, open and inactivated.

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Bezanilla, F. RNA editing of a human potassium channel modifies its inactivation. Nat Struct Mol Biol 11, 915–916 (2004). https://doi.org/10.1038/nsmb1004-915

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