Bacterial antisense RNAs target translation initiation regions (TIRs) to compete with ribosome binding, thus repressing translation and—secondarily—causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within the coding region, far downstream of the TIR.
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Wagner, E. Kill the messenger: bacterial antisense RNA promotes mRNA decay. Nat Struct Mol Biol 16, 804–806 (2009). https://doi.org/10.1038/nsmb0809-804
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DOI: https://doi.org/10.1038/nsmb0809-804
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