Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A SUMO ligase for ALT

Nature Structural & Molecular Biology volume 14, pages 570–571 (2007)Cite this article

A study in this issue implicates SUMOylation of telomere-binding proteins by the SMC5/6 complex in alternative lengthening of telomeres.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Involvement of SMC5/6 SUMO ligase MMS21 in APBs.

Kim Caesar

References

  1. Londono-Vallejo, J.A., Der-Sarkissian, H., Cazes, L., Bacchetti, S. & Reddel, R.R. Cancer Res. 64, 2324–2327 (2004).

    Article  CAS  Google Scholar 

  2. Bailey, S.M., Brenneman, M.A. & Goodwin, E.H. Nucleic Acids Res. 32, 3743–3751 (2004).

    Article  CAS  Google Scholar 

  3. Bechter, O.E., Zou, Y., Walker, W., Wright, W.E. & Shay, J.W. Cancer Res. 64, 3444–3451 (2004).

    Article  CAS  Google Scholar 

  4. Tokutake, Y. et al. Biochem. Biophys. Res. Commun. 247, 765–772 (1998).

    Article  CAS  Google Scholar 

  5. Yeager, T.R. et al. Cancer Res. 59, 4175–4179 (1999).

    CAS  Google Scholar 

  6. Potts, P.R. & Yu, H. Nat. Struct. Mol. Biol. 14, 581–590 (2007).

    Article  CAS  Google Scholar 

  7. Potts, P.R., Porteus, M.H. & Yu, H. EMBO J. 25, 3377–3388 (2006).

    Article  CAS  Google Scholar 

  8. Strom, L., Lindroos, H.B., Shirahige, K. & Sjogren, C. Mol. Cell 16, 1003–1015 (2004).

    Article  Google Scholar 

  9. Jiang, W.Q., Zhong, Z.H., Henson, J.D. & Reddel, R.R. Oncogene, published online 5 February 2007 (doi:10.1038/sj.onc.1210260).

    Article  CAS  Google Scholar 

  10. O'Connor, M.S., Safari, A., Liu, D., Qin, J. & Songyang, Z. J. Biol. Chem. 279, 28585–28591 (2004).

    Article  CAS  Google Scholar 

  11. Molenaar, C. et al. EMBO J. 22, 6631–6641 (2003).

    Article  CAS  Google Scholar 

  12. Cesare, A.J. & Griffith, J.D. Mol. Cell. Biol. 24, 9948–9957 (2004).

    Article  CAS  Google Scholar 

  13. Wang, R.C., Smogorzewska, A. & de Lange, T. Cell 119, 355–368 (2004).

    Article  CAS  Google Scholar 

  14. Fasching, C.L., Neumann, A.A., Muntoni, A., Yeager, T.R. & Reddel, R.R. Cancer Res. (in the press).

  15. Fasching, C.L., Bower, K. & Reddel, R.R. Cancer Res. 65, 2722–2729 (2005).

    Article  CAS  Google Scholar 

  16. Marciniak, R.A. et al. Cancer Res. 65, 2730–2737 (2005).

    Article  CAS  Google Scholar 

  17. Jiang, W.Q. et al. Mol. Cell. Biol. 25, 2708–2721 (2005).

    Article  CAS  Google Scholar 

  18. Perrem, K., Colgin, L.M., Neumann, A.A., Yeager, T.R. & Reddel, R.R. Mol. Cell. Biol. 21, 3862–3875 (2001).

    Article  CAS  Google Scholar 

  19. Ford, L.P. et al. J. Biol. Chem. 276, 32198–32203 (2001).

    Article  CAS  Google Scholar 

  20. Muntoni, A. & Reddel, R.R. Hum. Mol. Genet. 14 (Suppl 2), R191–R196 (2005).

    Article  CAS  Google Scholar 

  21. Dunham, M.A., Neumann, A.A., Fasching, C.L. & Reddel, R.R. Nat. Genet. 26, 447–450 (2000).

    Article  CAS  Google Scholar 

  22. Dynek, J.N. & Smith, S. Science 304, 97–100 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Roger R. Reddel is acting director of the Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia. rreddel@cmri.usyd.edu.au,

    Roger R Reddel

Authors
  1. Roger R Reddel
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reddel, R. A SUMO ligase for ALT. Nat Struct Mol Biol 14, 570–571 (2007). https://doi.org/10.1038/nsmb0707-570

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0707-570

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing