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Hsp90 structure: when two ends meet

Nature Structural & Molecular Biology volume 13, pages 478–480 (2006)Cite this article

The crystal structure of the full-length yeast Hsp90 sheds new light on the conformational cycle and the functional regulation of this important molecular chaperone.

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Figure 1: Working model of the conformational cycle of Hsp90.
Figure 2: Crystal structure of Hsp90 in complex with p23 (ref. 2).

References

  1. Young, J.C., Moarefi, I. & Hartl, F.U. J. Cell Biol. 154, 267–273 (2001).

    Article  CAS  Google Scholar 

  2. Ali, M.M.U. et al. Nature 440, 1013–1017 (2006).

    Article  CAS  Google Scholar 

  3. Scheufler, C. et al. Cell 101, 199–210 (2000).

    Article  CAS  Google Scholar 

  4. Whitesell, L. & Lindquist, S.L. Nat. Rev. Cancer 5, 761–772 (2005).

    Article  CAS  Google Scholar 

  5. Dutta, R. & Inouye, M. Trends Biochem. Sci. 25, 24–28 (2000).

    Article  CAS  Google Scholar 

  6. Huai, Q. et al. Structure 13, 579–590 (2005).

    Article  CAS  Google Scholar 

  7. Harris, S.F., Shiau, A.K. & Agard, D.A. Structure 12, 1087–1097 (2004).

    Article  CAS  Google Scholar 

  8. Richter, K., Walter, S. & Buchner, J. J. Mol. Biol. 342, 1403–1413 (2004).

    Article  CAS  Google Scholar 

  9. Richter, K., Reinstein, J. & Buchner, J. J. Biol. Chem. 277, 44905–44910 (2002).

    Article  CAS  Google Scholar 

  10. Meyer, P. et al. Mol. Cell 11, 647–658 (2003).

    Article  CAS  Google Scholar 

  11. Meyer, P. et al. EMBO J. 23, 511–519 (2004).

    Article  CAS  Google Scholar 

  12. Harst, A., Lin, H. & Obermann, W.M. Biochem. J. 387, 789–796 (2005).

    Article  CAS  Google Scholar 

  13. Johnson, J.L. & Toft, D.O. J. Biol. Chem. 269, 24989–24993 (1994).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried, 82152, Germany

    Andreas Bracher & F Ulrich Hartl

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  1. Andreas Bracher
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  2. F Ulrich Hartl
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Bracher, A., Hartl, F. Hsp90 structure: when two ends meet. Nat Struct Mol Biol 13, 478–480 (2006). https://doi.org/10.1038/nsmb0606-478

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