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The human Pol III transcriptome and gene information flow

Nature Structural & Molecular Biology volume 17, pages 539–541 (2010)Cite this article

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In this issue, three papers report the distribution of the RNA polymerase III (Pol III) machinery, including transcription factor IIIB, transcription factor IIIC and Pol III itself, across the human genome. These studies reveal cell type–specific expression of Pol III genes, functional interplay between the Pol II and Pol III transcriptional machineries and the potential involvement of Pol III genes in chromosome organization.

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Figure 1: Schematic representation of three typical loci exemplifying cross-regulation of Pol III and Pol II transcription.

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Authors and Affiliations

  1. Ken-ichi Noma is at The Wistar Institute, Philadelphia, Pennsylvania, USA.,

    Ken-ichi Noma

  2. Rohinton T. Kamakaka is in the Department of Molecular Cell & Developmental Biology, University of California, Santa Cruz, California, USA.,

    Rohinton T Kamakaka

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  1. Ken-ichi Noma
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  2. Rohinton T Kamakaka
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Correspondence to Ken-ichi Noma or Rohinton T Kamakaka.

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The authors declare no competing financial interests.

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Noma, Ki., Kamakaka, R. The human Pol III transcriptome and gene information flow. Nat Struct Mol Biol 17, 539–541 (2010). https://doi.org/10.1038/nsmb0510-539

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