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SIN-fully silent: HDAC complexes in fission yeast

Nature Structural & Molecular Biology volume 14, pages 358–359 (2007)Cite this article

Proper establishment, maintenance and removal of covalent post-translational modifications on histones are essential for normal cell physiology. In this issue, Nicolas et al. describe the characterization of two physically and functionally distinct Clr6 (Rpd3)-containing histone deacetylase complexes in fission yeast and implicate their activity in a number of processes, including transcriptional regulation, silencing and genomic integrity.

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Figure 1: Comparison between Rpd3 (Clr6) complexes in S. cerevisiae and S. pombe.

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Acknowledgements

We thank C.J. Ingles and G. Cagney for critically reading the manuscript, M. Shales for help with artwork and R. Rothstein and D. Alvaro for sharing unpublished results.

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  1. Department of Cellular and Molecular Pharmacology, Assen Roguev and Nevan J. Krogan are at the University of California, San Francisco, San Francisco, California, 94158, USA. krogan@cmp.ucsf.edu,

    Assen Roguev & Nevan J Krogan

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  1. Assen Roguev
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Roguev, A., Krogan, N. SIN-fully silent: HDAC complexes in fission yeast. Nat Struct Mol Biol 14, 358–359 (2007). https://doi.org/10.1038/nsmb0507-358

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