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A leak in the EAATs

Nature Structural & Molecular Biology volume 14, pages 356–357 (2007)Cite this article

Glutamate transporters in neuronal membranes are also known to catalyze a 'leak' of chloride ions, for unknown biological purposes. Now a glutamate transporter homolog from evolutionarily distant microorganisms has been shown to contain a similar chloride leak.

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Figure 1: Scheme of cotransport by an alternating-site mechanism.

Katie Ris

Figure 2: Relief of membrane polarization by Cl− leak.

Katie Ris

References

  1. Yernool, D., Boudker, O., Jin, Y. & Gouaux, E. Nature 431, 811–818 (2004).

    Article  CAS  Google Scholar 

  2. Boudker, O., Ryan, R.M., Yernool, D., Shimamoto, K. & Gouaux, E. Nature 445, 387–393 (2007).

    Article  CAS  Google Scholar 

  3. Ryan, R.M & Mindell, J.A. Nat. Struct. Mol. Biol. 14, 365–371 (2007).

    Article  CAS  Google Scholar 

  4. Maloney, P.C. Curr. Opin. Cell Biol. 6, 571–582 (1994).

    Article  CAS  Google Scholar 

  5. Abramson, J. et al. Science 301, 610–615 (2003).

    Article  CAS  Google Scholar 

  6. Yin, Y., He, X., Szewczyk, P., Nguyen, T. & Chang, G. Science 312, 741–744 (2006).

    Article  CAS  Google Scholar 

  7. Huang, Y., Lemieux, M.J., Song, J., Auer, M. & Wang, D.N. Science 301, 616–620 (2003).

    Article  CAS  Google Scholar 

  8. Fairman, W.A., Vandenberg, R.J., Arriza, J.L., Kavanaugh, M.P. & Amara, S.G. Nature 375, 599–603 (1995).

    Article  CAS  Google Scholar 

  9. Veruki, M.L., Morkve, S.H. & Hartveit, E. Nat. Neurosci. 9, 1388–1396 (2006).

    Article  CAS  Google Scholar 

  10. Wersinger, E. et al. J. Physiol. (Lond.) 577, 221–234 (2006).

    Article  CAS  Google Scholar 

  11. Ryan, R.M., Mitrovic, A.D. & Vandenberg, R.J. J. Biol. Chem. 279, 20742–20751 (2004).

    Article  CAS  Google Scholar 

  12. Defelice, L.J. & Goswami, T. Annu. Rev. Physiol. 69, 87–112 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Christopher Miller is in the Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA. cmiller@brandeis.edu,

    Christopher Miller

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  1. Christopher Miller
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The author declares no competing financial interests.

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Miller, C. A leak in the EAATs. Nat Struct Mol Biol 14, 356–357 (2007). https://doi.org/10.1038/nsmb0507-356

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