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Mediating repair

Nature Structural & Molecular Biology volume 12, pages 213–214 (2005)Cite this article

The tumor suppressor protein BRCA2 promotes efficient repair of damaged chromosomes by homologous recombination, and it does so by influencing the activity of the Rad51 recombinase. A new biochemical study on the Ustilago maydis BRCA2 ortholog Brh2 sheds light on the molecular function of this tumor suppressor in the Rad51-mediated homologous recombination reaction.

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Figure 1: DNA double-strand break repair by homologous recombination.
Figure 2: Recombination mediator activity of the Brh2 protein.

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Acknowledgements

I thank S. Van Komen for help in artwork preparation.

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  1. the Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Sterling Hall of Medicine, 333 Cedar Street, New Haven, 06520, Connecticut, USA

    Patrick Sung

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Sung, P. Mediating repair. Nat Struct Mol Biol 12, 213–214 (2005). https://doi.org/10.1038/nsmb0305-213

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