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Directing mRNA export

A recent study on the RNA-binding protein Npl3p reveals how its direct interaction with the mRNA export receptor Mex67p is regulated by phosphorylation and how this post-translational modification contributes to the assembly and disassembly of mRNP export complexes.

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Figure 1: Model for the phosphorylation and dephosphorylation cycles of Npl3p.

References

  1. Suntharalingam, M. & Wente, S.R. Dev. Cell 4, 775–789 (2003).

    Article  CAS  Google Scholar 

  2. Stutz, F. & Izaurralde, E. Trends Cell. Biol. 13, 319–327 (2003).

    Article  CAS  Google Scholar 

  3. Reed, R. & Hurt, E. Cell 108, 523–531 (2002).

    Article  CAS  Google Scholar 

  4. Gilbert, W. & Guthrie, C. Mol. Cell 13, 201–212 (2004).

    Article  CAS  Google Scholar 

  5. Weis, K. Curr. Opin. Cell Biol. 14, 328–335 (2002).

    Article  CAS  Google Scholar 

  6. Snay-Hodge, C.A., Colot, H.V., Goldstein, A.L. & Cole, C.N. EMBO J. 17, 2663–2676 (1998).

    Article  CAS  Google Scholar 

  7. Tseng S.S. et al. EMBO J. 17, 2651–2662 (1998).

    Article  CAS  Google Scholar 

  8. Schmitt, C. et al. EMBO J. 18, 4332–4347 (1999).

    Article  CAS  Google Scholar 

  9. Maquat, L.E. Nature Rev. Mol. Cell Biol. 5, 89–99 (2004).

    Article  CAS  Google Scholar 

  10. Ohno, M., Segref, A., Bachi, A., Wilm, M. & Mattaj, I.W. Cell 101, 187–198 (2000).

    Article  CAS  Google Scholar 

  11. Graveley, B.R. RNA 6, 1197–1211 (2000).

    Article  CAS  Google Scholar 

  12. Lee, M.S., Henry, M., & Silver, P.A. Genes Dev. 10, 1233–1246 (1996).

    Article  CAS  Google Scholar 

  13. Singleton, D.R., Chen, S., Hitomi, M., Kumagai, C. & Tartakoff, A.M. J. Cell Sci. 108, 265–272 (1995).

    CAS  PubMed  Google Scholar 

  14. Russell, I. & Tollervey, D. Eur. J. Cell Biol. 66, 293–301 (1995).

    CAS  PubMed  Google Scholar 

  15. Lei, E.P., Krebber, H., & Silver, P.A. Genes Dev. 15, 1771–1782 (2001).

    Article  CAS  Google Scholar 

  16. Gilbert, W., Siebel, C.W., & Guthrie, C. RNA 7, 302–313 (2001).

    Article  CAS  Google Scholar 

  17. Yun, C.Y. & Fu, X.D. J. Cell Biol. 150, 707–718 (2000).

    Article  CAS  Google Scholar 

  18. Feng, Z.H. et al. J. Biol. Chem. 266, 23796–23801 (1991).

    CAS  PubMed  Google Scholar 

  19. Misteli, T. & Spector, D.L. (1996). Mol. Biol. Cell. 7, 1559–1572 (1996).

    Article  CAS  Google Scholar 

  20. Misteli, T. et al. J. Cell Biol. 143, 297–307 (1998).

    Article  CAS  Google Scholar 

  21. Kim, E., Du, L., Bregman, D.B., and Warren, S.L. J. Cell Biol. 136, 19–28 (1997).

    Article  CAS  Google Scholar 

  22. Jensen, T.H., Dower, K., Libri, D. & Rosbash, M. Mol. Cell 11, 1129–1138 (2003).

    Article  CAS  Google Scholar 

  23. Huang, Y., Gattoni, R., Stevenin, J., & Steitz, J.A. Mol. Cell 11, 837–843 (2003).

    Article  CAS  Google Scholar 

Download references

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Izaurralde, E. Directing mRNA export. Nat Struct Mol Biol 11, 210–212 (2004). https://doi.org/10.1038/nsmb0304-210

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