An immense range of polysaccharide structures is expressed on the bacterial surface. The length of the polymer can be a crucial attribute for virulence. Members of a family of 'polysaccharide copolymerase' proteins are essential for the regulation of polymer chain length, participating in one widespread biosynthesis scheme.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines
npj Vaccines Open Access 10 December 2021
-
Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus
Nature Communications Open Access 29 March 2019
-
Phylum-wide analysis of genes/proteins related to the last steps of assembly and export of extracellular polymeric substances (EPS) in cyanobacteria
Scientific Reports Open Access 06 October 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Raetz, C.R. & Whitfield, C. Annu. Rev. Biochem. 71, 635–700 (2002).
Whitfield, C. Annu. Rev. Biochem. 75, 39–68 (2006).
Morona, R. et al. Microbiology 146, 1–4 (2000).
Daniels, C. et al. Environ. Microbiol. 4, 883–897 (2002).
Tocilj, A. et al. Nat. Struct. Mol. Biol. 15, 130–138 (2008).
Batchelor, R.A. et al. J. Bacteriol. 173, 5699–5704 (1991).
Grangeasse, C. et al. Trends Biochem. Sci. 32, 86–94 (2007).
Dong, C. et al. Nature 444, 226–229 (2006).
Collins, R.F. et al. Proc. Natl. Acad. Sci. USA 104, 2390–2395 (2007).
Tang, K.H. et al. Biochemistry 46, 11744–11752 (2007).
Marolda, C.L. et al. J. Bacteriol. (in the press) 190, (2008).
Marolda, C.L. et al. J. Bacteriol. 188, 5124–5135 (2006).
Bastin, D.A. et al. Mol. Microbiol. 7, 725–734 (1993).
Morona, R. et al. J. Bacteriol. 177, 1059–1068 (1995).
Daniels, C. et al. Mol. Microbiol. 28, 1211–1222 (1998).
Saldiás, M.S. et al. Microbiology 154, 440–453 (2008).
Goldman, R.C. & Hunt, F. J. Bacteriol. 172, 5352–5359 (1990).
Wu, T. et al. Proc. Natl. Acad. Sci. USA 103, 11754–11759 (2006).
Sperandeo, P. et al. J. Bacteriol. 189, 244–253 (2007).
Collins, R.F. et al. J. Biol. Chem. 281, 2144–2150 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Whitfield, C., Larue, K. Stop and go: regulation of chain length in the biosynthesis of bacterial polysaccharides. Nat Struct Mol Biol 15, 121–123 (2008). https://doi.org/10.1038/nsmb0208-121
Issue Date:
DOI: https://doi.org/10.1038/nsmb0208-121
This article is cited by
-
Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines
npj Vaccines (2021)
-
Biological Soil Crusts from Different Soil Substrates Harbor Distinct Bacterial Groups with the Potential to Produce Exopolysaccharides and Lipopolysaccharides
Microbial Ecology (2020)
-
Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus
Nature Communications (2019)
-
Phylum-wide analysis of genes/proteins related to the last steps of assembly and export of extracellular polymeric substances (EPS) in cyanobacteria
Scientific Reports (2015)
-
Bacterial polymers: biosynthesis, modifications and applications
Nature Reviews Microbiology (2010)