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Stop and go: regulation of chain length in the biosynthesis of bacterial polysaccharides

An immense range of polysaccharide structures is expressed on the bacterial surface. The length of the polymer can be a crucial attribute for virulence. Members of a family of 'polysaccharide copolymerase' proteins are essential for the regulation of polymer chain length, participating in one widespread biosynthesis scheme.

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Figure 1: Current working model for the biosynthesis and assembly of lipid polysaccharide (LPS) O-antigen in a Wzy-dependent process1,2.

Kim Caesar

References

  1. Raetz, C.R. & Whitfield, C. Annu. Rev. Biochem. 71, 635–700 (2002).

    Article  CAS  Google Scholar 

  2. Whitfield, C. Annu. Rev. Biochem. 75, 39–68 (2006).

    Article  CAS  Google Scholar 

  3. Morona, R. et al. Microbiology 146, 1–4 (2000).

    Article  CAS  Google Scholar 

  4. Daniels, C. et al. Environ. Microbiol. 4, 883–897 (2002).

    Article  CAS  Google Scholar 

  5. Tocilj, A. et al. Nat. Struct. Mol. Biol. 15, 130–138 (2008).

    Article  CAS  Google Scholar 

  6. Batchelor, R.A. et al. J. Bacteriol. 173, 5699–5704 (1991).

    Article  CAS  Google Scholar 

  7. Grangeasse, C. et al. Trends Biochem. Sci. 32, 86–94 (2007).

    Article  CAS  Google Scholar 

  8. Dong, C. et al. Nature 444, 226–229 (2006).

    Article  CAS  Google Scholar 

  9. Collins, R.F. et al. Proc. Natl. Acad. Sci. USA 104, 2390–2395 (2007).

    Article  CAS  Google Scholar 

  10. Tang, K.H. et al. Biochemistry 46, 11744–11752 (2007).

    Article  CAS  Google Scholar 

  11. Marolda, C.L. et al. J. Bacteriol. (in the press) 190, (2008).

  12. Marolda, C.L. et al. J. Bacteriol. 188, 5124–5135 (2006).

    Article  CAS  Google Scholar 

  13. Bastin, D.A. et al. Mol. Microbiol. 7, 725–734 (1993).

    Article  CAS  Google Scholar 

  14. Morona, R. et al. J. Bacteriol. 177, 1059–1068 (1995).

    Article  CAS  Google Scholar 

  15. Daniels, C. et al. Mol. Microbiol. 28, 1211–1222 (1998).

    Article  CAS  Google Scholar 

  16. Saldiás, M.S. et al. Microbiology 154, 440–453 (2008).

    Article  Google Scholar 

  17. Goldman, R.C. & Hunt, F. J. Bacteriol. 172, 5352–5359 (1990).

    Article  CAS  Google Scholar 

  18. Wu, T. et al. Proc. Natl. Acad. Sci. USA 103, 11754–11759 (2006).

    Article  CAS  Google Scholar 

  19. Sperandeo, P. et al. J. Bacteriol. 189, 244–253 (2007).

    Article  CAS  Google Scholar 

  20. Collins, R.F. et al. J. Biol. Chem. 281, 2144–2150 (2006).

    Article  CAS  Google Scholar 

Download references

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Whitfield, C., Larue, K. Stop and go: regulation of chain length in the biosynthesis of bacterial polysaccharides. Nat Struct Mol Biol 15, 121–123 (2008). https://doi.org/10.1038/nsmb0208-121

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