The monoallelic expression of many imprinted genes in mammals depends on DNA methylation marks that originate from the germ cells. Recent studies in mice and fruit flies evoke a novel, transient mode of genomic imprinting in which oocyte-acquired histone H3 Lys27 trimethylation (H3K27me3) marks are transmitted to the zygote and modulate the allele specificity and timing of gene expression in the early embryo.
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References
Feil, R. & Berger, F. Trends Genet. 23, 192–199 (2007).
Kelsey, G. & Feil, R. Phil. Trans. R. Soc. Lond. B 368, 20110336 (2013).
Okae, H. et al. Hum. Mol. Genet. 21, 548–558 (2012).
Okae, H. et al. Hum. Mol. Genet. 23, 992–1001 (2014).
Henckel, A. et al. Hum. Mol. Genet. 18, 3375–3383 (2009).
Inoue, A., Jiang, L., Lu, F., Suzuki, T. & Zhang, Y. Nature 547, 419–424 (2017).
Zenk, F. et al. Science 357, 212–216 (2017).
Zheng, H. et al. Mol. Cell 63, 1066–1079 (2016).
Erhardt, S. et al. Development 130, 4235–4248 (2003).
Burton, A. & Torres-Padilla, M.E. Nat. Rev. Mol. Cell Biol. 15, 723–734 (2014).
Greenberg, M.V. et al. Nat. Genet. 49, 110–118 (2017).
Auclair, G. et al. Genome Res. 26, 192–202 (2016).
Miri, K. et al. Development 140, 4480–4489 (2013).
Moreno-Romero, J., Jiang, H., Santos-González, J. & Köhler, C. EMBO J. 35, 1298–1311 (2016).
Voon, H.P. et al. Cell Rep. 11, 405–418 (2015).
Renfree, M.B., Suzuki, S. & Kaneko-Ishino, T. Phil. Trans. R. Soc. Lond. B 368, 20120151 (2013).
Sanchez-Delgado, M. et al. PLoS Genet. 12, e1006427 (2016).
Takagi, N. Semin. Cell Dev. Biol. 14, 319–329 (2003).
Sado, T., Okano, M., Li, E. & Sasaki, H. Development 131, 975–982 (2004).
Khosla, S., Mendiratta, G. & Brahmachari, V. Cytogenet. Genome Res. 113, 41–52 (2006).
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Pathak, R., Feil, R. Oocyte-derived histone H3 lysine 27 methylation controls gene expression in the early embryo. Nat Struct Mol Biol 24, 685–686 (2017). https://doi.org/10.1038/nsmb.3456
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DOI: https://doi.org/10.1038/nsmb.3456
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Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage
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