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Break-induced replication: an unhealthy choice for stress relief?

Nature Structural & Molecular Biology volume 24, pages 11–12 (2017)Cite this article

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Determining the molecular mechanisms responsible for trinucleotide DNA repeat expansions is critical, as such expansions underlie many neuromuscular and neurodegenerative disorders. Mirkin and colleagues now propose that large-scale expansions of trinucleotide repeats can be generated by DNA-break-induced replication.

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Figure 1: Origin and consequences of break-induced replication.

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Acknowledgements

This work was supported by NIGMS (grant GM084242).

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Authors and Affiliations

  1. Beth Osia and Anna Malkova are at the Department of Biology, Juraj Kramara, University of Iowa, Iowa City, Iowa, USA.,

    Juraj Kramara, Beth Osia & Anna Malkova

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  1. Juraj Kramara
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  2. Beth Osia
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  3. Anna Malkova
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Correspondence to Anna Malkova.

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Kramara, J., Osia, B. & Malkova, A. Break-induced replication: an unhealthy choice for stress relief?. Nat Struct Mol Biol 24, 11–12 (2017). https://doi.org/10.1038/nsmb.3361

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