Bacteria and phages are engaged in a molecular arms race, constantly coevolving to best each other. The crystal structure of the anti-CRISPR protein AcrF3 bound to Cas3, an essential component of CRISPR-based immunity, sheds light on how phages have found ways to suppress bacterial immunity.
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Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
BMC Biology Open Access 19 March 2018
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Mallon, J., Bailey, S. A molecular arms race: new insights into anti-CRISPR mechanisms. Nat Struct Mol Biol 23, 765–766 (2016). https://doi.org/10.1038/nsmb.3287
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DOI: https://doi.org/10.1038/nsmb.3287