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Good cap/bad cap: how the cap-binding complex determines RNA fate

Nature Structural & Molecular Biology volume 21, pages 9–12 (2014)Cite this article

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Every RNA polymerase II transcript receives a 5′-end 7-methylguanosine (m7G) cap, which is rapidly bound by the nuclear cap–binding complex (CBC). Two recent studies now reveal that the CBC associates with a variety of effector proteins that enable it to interrogate nascent RNA, discriminating between distinct RNA subclasses and routing them either toward distinct maturation pathways or toward decay. Thus, the CBC has an early role in policing cellular RNA.

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Figure 1: Fate of nascent Pol II transcript subclasses.

Katie Vicari

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Authors and Affiliations

  1. Michaela Müller-McNicoll and Karla M. Neugebauer are at the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.,

    Michaela Müller-McNicoll & Karla M Neugebauer

  2. Karla M. Neugebauer is also at the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA.,

    Karla M Neugebauer

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  1. Michaela Müller-McNicoll
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Correspondence to Karla M Neugebauer.

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Müller-McNicoll, M., Neugebauer, K. Good cap/bad cap: how the cap-binding complex determines RNA fate. Nat Struct Mol Biol 21, 9–12 (2014). https://doi.org/10.1038/nsmb.2751

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