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Poly-combing the genome for RNA

Nature Structural & Molecular Biology volume 20, pages 1344–1346 (2013)Cite this article

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An unresolved question in mammalian epigenetic regulation is how ubiquitously expressed chromatin-modifying complexes such as Polycomb group complex 2 (PRC2) find their specific target sites across an intricate choreography of localization events in time and space. Two recent studies now provide critical new insights into an intriguing genome-wide role for RNA in PRC2 regulation.

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Figure 1: Proposed models for PRC2-RNA interactions.
Figure 2: The effect of RNA binding on PRC2 activity.

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Author notes

  1. Loyal Goff is also at the Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

  2. John Rinn is also at the Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Authors and Affiliations

  1. Loyal A. Goff and John L. Rinn are at the Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, Massachusetts, USA, and the Broad Institute, Cambridge, Massachusetts, USA.,

    Loyal A Goff & John L Rinn

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  1. Loyal A Goff
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  2. John L Rinn
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Correspondence to John L Rinn.

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The authors declare no competing financial interests.

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Goff, L., Rinn, J. Poly-combing the genome for RNA. Nat Struct Mol Biol 20, 1344–1346 (2013). https://doi.org/10.1038/nsmb.2728

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