Eukaryotic mRNAs containing nonsense codons are degraded by nonsense-mediated mRNA decay (NMD). In humans, NMD was proposed to act exclusively on newly synthesized mRNA during a 'pioneer round' of translation, when mRNA is associated with the nuclear cap-binding complex (CBC). Two reports now challenge this view, revealing that NMD is independent of whether CBC or the cytoplasmic cap-binding protein (eIF4E) promotes translation and can occur later in an mRNA's life.
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Hentze, M., Izaurralde, E. Making sense of nonsense. Nat Struct Mol Biol 20, 651–653 (2013). https://doi.org/10.1038/nsmb.2601
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DOI: https://doi.org/10.1038/nsmb.2601