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Expanding the functional repertoire of macrodomains

Nature Structural & Molecular Biology volume 20, pages 407–408 (2013)Cite this article

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Macrodomains are conserved globular domains that can interact with, and in some cases modify, ADP-ribose–based molecules. In this issue, two reports add to the functional repertoire of this domain, by demonstrating that a subset of macrodomain-containing proteins functions to catalyze the removal of protein-proximal ADP-ribose.

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Figure 1: ADP-ribosylation is reversed by macrodomain-mediated ADP-ribosyl hydrolysis.

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Acknowledgements

The author would like to thank T. Zhang for critical reading of the manuscript.

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Authors and Affiliations

  1. Matthew J. Gamble is at the Department of Molecular Pharmacology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA.,

    Matthew J Gamble

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  1. Matthew J Gamble
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Correspondence to Matthew J Gamble.

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The author declares no competing financial interests.

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Gamble, M. Expanding the functional repertoire of macrodomains. Nat Struct Mol Biol 20, 407–408 (2013). https://doi.org/10.1038/nsmb.2552

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