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Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD

Nature Structural & Molecular Biology volume 19, pages 979–981 (2012)Cite this article

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Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the endoplasmic reticulum–resident rhomboid protease RHBDL4 facilitates ERAD by recognizing and cleaving integral membrane substrates. The work indicates that intramembrane proteolysis may have a general role in the extraction of misfolded membrane proteins from the endoplasmic reticulum.

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Figure 1
Figure 2: Roles for the rhomboid family in ERAD.

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Authors and Affiliations

  1. Department of Embryology, Ethan J. Greenblatt is at the Howard Hughes Medical Institute Research Laboratories, Carnegie Institution of Washington, Baltimore, Maryland, USA.,

    Ethan J Greenblatt

  2. Department of Biology, James A. Olzmann and Ron R. Kopito are at Stanford University, Stanford, California, USA.,

    James A Olzmann & Ron R Kopito

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  1. Ethan J Greenblatt
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  2. James A Olzmann
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  3. Ron R Kopito
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Correspondence to Ron R Kopito.

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The authors declare no competing financial interests.

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Greenblatt, E., Olzmann, J. & Kopito, R. Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD. Nat Struct Mol Biol 19, 979–981 (2012). https://doi.org/10.1038/nsmb.2398

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