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Chromatin 'resetting' during transcription elongation: a central role for methylated H3K36

Nature Structural & Molecular Biology volume 19, pages 863–864 (2012)Cite this article

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A number of events must occur to preserve the integrity of the chromatin template during gene transcription. A study in this issue reveals a novel mechanism whereby chromatin remodelers are recruited to histone modifications within gene bodies to prevent aberrant histone exchange during transcriptional elongation.

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Figure 1: Set2 and histone H3K36 methylation safeguard transcription elongation.

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Authors and Affiliations

  1. Jill S. Butler and Sharon Y.R. Dent are at the Department of Molecular Carcinogenesis at The Virginia Harris Cockrell Cancer Research Center, University of Texas MD Anderson Cancer Center, Smithville, Texas, USA, and the Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.,

    Jill S Butler & Sharon Y R Dent

  2. Sharon Y.R. Dent is also at the Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.,

    Sharon Y R Dent

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  1. Jill S Butler
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  2. Sharon Y R Dent
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Correspondence to Sharon Y R Dent.

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The authors declare no competing financial interests.

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Butler, J., Dent, S. Chromatin 'resetting' during transcription elongation: a central role for methylated H3K36. Nat Struct Mol Biol 19, 863–864 (2012). https://doi.org/10.1038/nsmb.2370

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