Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

The lymphoproliferation mutation in Fas locally unfolds the Fas death domain

Nature Structural Biology volume 4, pages 983–985 (1997)Cite this article

NMR studies of the lymphoproliferation mutant (V238N) of the Fas death domain indicate that helix 3 is unfolded. This local structural change abolishes binding to FADD — a protein that interacts with Fas and also contains a death domain — and causes the accumulation of autoreactive T cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Itho, N. et al. Cell 66, 233–243 (1991).

    Article  Google Scholar 

  2. Oehm, A . et al. J. Biol. Chem. 267, 10709–10715 (1992).

    CAS  PubMed  Google Scholar 

  3. Nagata, S. & Goldstein, P. Science 267, 1449–1456 (1995).

    Article  CAS  Google Scholar 

  4. Ju, S.T. et al. Nature 373, 444–448 (1995).

    Article  CAS  Google Scholar 

  5. Bellgrau, D. et al. Nature 377, 630–632 (1995).

    Article  CAS  Google Scholar 

  6. Griffith, T.S., Brunner, T., Fletcher, S.M., Green, D.R. & Ferguson, T.A. Science 270, 1189–1192 (1995).

    Article  CAS  Google Scholar 

  7. Chinnaiyan, A.M., O'Rourke, K., Tewari, M. & Dixit, V.M. Cell 81, 505–512 (1995).

    Article  CAS  Google Scholar 

  8. Boldin, M.P. et al. J. Biol. Chem. 270, 7795–7798 (1995).

    Article  CAS  Google Scholar 

  9. Alnemri, E.S. et al. Cell 87, 171 (1996).

    Article  CAS  Google Scholar 

  10. Muzio, M. et al. Cell, 85, 817–827 (1996).

    Article  CAS  Google Scholar 

  11. Boldin, M.P., Goncharov, T.M., Goltsev, Y.V. & Wallach, D. Cell 81, 803–816 (1996).

    Article  Google Scholar 

  12. Nagata, S. Curr. Biol. 6, 1241–1243 (1996).

    Article  CAS  Google Scholar 

  13. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. & Nagata, S. Nature 356, 314–317 (1992).

    Article  CAS  Google Scholar 

  14. Cohen, P.L. & Eisenberg, R.A. Annu. Rev. Immun. 9, 243–269 (1991).

    Article  CAS  Google Scholar 

  15. Huang, B., Eberstadt, M., Olejniczak, E.T., Meadows, R.P. & Fesik, S.W. Nature 384, 638–641 (1996).

    Article  CAS  Google Scholar 

  16. Yamazaki, T., Lee, W., Arrowsmith, C H., Muhandiram, D.R. & Kay, L.E. J. Am. Chem. Soc. 116, 11655–11666 (1994).

    Article  CAS  Google Scholar 

  17. Clore, M. & Groneborn, A.M. Meth. Enz. 239, 349–363 (1994).

    Article  CAS  Google Scholar 

  18. Pace, C.N. Meth. Enz. 131, 266–280 (1986).

    Article  CAS  Google Scholar 

  19. Liang, H. & Trewilliger, T.C. Biochemistry 30, 2772–2782 (1991).

    Article  CAS  Google Scholar 

  20. Deleage, G. & Geourjon, C. CABIOS 9, 197–199 (1993).

    CAS  PubMed  Google Scholar 

  21. Yang, J.T., Wu, C. -S. C. & Martinez, H. M. Meth. Enz. 130, 208–269 (1986).

    Article  CAS  Google Scholar 

  22. Spera, S. & Bax, A. J. Am. Chem. Soc. 113, 5490–5492 (1991).

    Article  CAS  Google Scholar 

  23. Wishart, D.S. Sykes B.D. Meth. Enz. 239, 363–392 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abbott Laboratories, D47G, AP10, Abbott Park, illinois, 60064-3500, USA

    Matthias Eberstadt, Baohua Huang, Edward T. Olejniczak & Stephen W. Fesik

Authors
  1. Matthias Eberstadt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Baohua Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Edward T. Olejniczak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Stephen W. Fesik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephen W. Fesik.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eberstadt, M., Huang, B., Olejniczak, E. et al. The lymphoproliferation mutation in Fas locally unfolds the Fas death domain. Nat Struct Mol Biol 4, 983–985 (1997). https://doi.org/10.1038/nsb1297-983

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb1297-983

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing