New structures of SH3 domains complexed with proline-rich peptides show that the ligands can bind in two opposite orientations; this feature has not been seen before in protein/protein recognition.
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Saraste, M., Musacchio, A. Backwards and forwards binding. Nat Struct Mol Biol 1, 835–837 (1994). https://doi.org/10.1038/nsb1294-835
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DOI: https://doi.org/10.1038/nsb1294-835
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