Abstract
Ribozymes that are sensitive to cyclic nucleotides have been selected in vitro. Remarkably, the cGMP-dependent ribozymes are specifically activated by a factor of 5,000 — the largest allosteric ribozyme activation by a small molecule seen to date.
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Modulating RNA structure and catalysis: lessons from small cleaving ribozymes
Cellular and Molecular Life Sciences Open Access 30 August 2009
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Marshall, K., Ellington, A. Training ribozymes to switch. Nat Struct Mol Biol 6, 992–994 (1999). https://doi.org/10.1038/14872
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DOI: https://doi.org/10.1038/14872
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