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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

Nature Structural Biology volume 4, pages 796–801 (1997)Cite this article

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 strauroporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.

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Author notes

  1. Alison M. Lawrie and Martin E.M. Noble: made equal contributions to this work

Authors and Affiliations

  1. Laboratory of Molecular Biophysics and Oxford Centre for Molecular Sciences, Rex Richards Building, South Parks Road, Oxford, 0X1 3QU, UK

    Paul Tunnah, Nicholas R. Brown, Louise N. Johnson & Jane A. Endicott

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  1. Alison M. Lawrie
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  2. Martin E.M. Noble
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  3. Paul Tunnah
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Lawrie, A., Noble, M., Tunnah, P. et al. Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2. Nat Struct Mol Biol 4, 796–801 (1997). https://doi.org/10.1038/nsb1097-796

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