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Proposed structure of the A domains of factor VIII by homology modelling

Nature Structural Biology volume 2, pages 740–744 (1995)Cite this article

We have predicted a structure for the three A domains of blood coagulation factor VIII by virtue of their homology to blue copper-binding proteins. This structure, consisting of six β-barrels, is arranged in a triangular configuration with a single type II copper-binding site linking the A1 and A3 domains.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, University of California, San Francisco, USA

    Yang Pan & Jane Gitschier

  2. Graduate Group in Biophysics, University of California, San Francisco, USA

    Tom DeFay

  3. Dept. of Medicine, University of California, San Francisco, USA

    Jane Gitschier & Fred E. Cohen

  4. Dept. of Pediatrics, University of California, San Francisco, USA

    Jane Gitschier

  5. Dept. of Pharmaceutical Chemistry, University of California, San Francisco, USA

    Fred E. Cohen

  6. Dept. of Cellular and Molecular Pharmacology, University of California, San Francisco, USA

    Fred E. Cohen

Authors
  1. Yang Pan
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  2. Tom DeFay
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  3. Jane Gitschier
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  4. Fred E. Cohen
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Pan, Y., DeFay, T., Gitschier, J. et al. Proposed structure of the A domains of factor VIII by homology modelling. Nat Struct Mol Biol 2, 740–744 (1995). https://doi.org/10.1038/nsb0995-740

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