Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Probing plant polyketide biosynthesis

Nature Structural Biology volume 6, pages 714–716 (1999)Cite this article

Abstract

The first structure of a chalcone synthase has been determined. Enzymes in this family have broad substrate specificities and participate in the biosynthesis of many secondary plant products, including compounds that provide defense against pathogens and precursors to the bitter acids in hops that flavor beer.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Reaction of CHS.
Figure 2: CHS-type reactions performed by enzymes using other substrates (in red).
Figure 3
Figure 4: Reaction performed by the pyrone synthase from G. hybrida.

References

  1. Ferrer, J.-L., Jez, J.M., Bowman, M.E., Dixon, R.A. & Noel, J.P. Nature Struct. Biol. 775– 784 (1999).

  2. Lukacin, R. et al. FEBS Lett. 448, 135– 140 (1999).

    Article  CAS  Google Scholar 

  3. Junghanns, K.T. et al. Plant Mol. Biol. 27, 681– 692 (1995).

    Article  CAS  Google Scholar 

  4. Beerhues, L. FEBS Lett. 383, 264–266 (1996).

    Article  CAS  Google Scholar 

  5. Schmidt, W. & Beerhues, L. FEBS Lett. 420, 143–146 (1997).

    Article  CAS  Google Scholar 

  6. Paniego, N. B. et al. Eur. J. Biochem. 262, 612– 616 (1999).

    Article  CAS  Google Scholar 

  7. Schüz, R., Heller, W. & Hahlbrock, K. J. Biol. Chem. 258, 6730– 6734 (1983).

    PubMed  Google Scholar 

  8. Gorham, J. The biochemistry of the stilbenoids. (Chapman & Hall, London; 1995).

    Google Scholar 

  9. Stark-Lorenzen, P., Nelke, B., Hänssler, G., Mühlbach, H.P. & Thomzik, J.E. Plant Cell Rep. 16, 668–673 ( 1997).

    Article  CAS  Google Scholar 

  10. Leckband, G. & Lörz, H. Theor. Appl. Genet. 96, 1004–1012 (1998).

    Article  CAS  Google Scholar 

  11. Jang, M. et al. Science 275, 218–220 (1997).

    Article  CAS  Google Scholar 

  12. Fliegmann, J., Schröder, G., Schanz, S., Britsch, L. & Schröder, J. Plant Mol. Biol. 18, 489–503 (1992).

    Article  CAS  Google Scholar 

  13. Sparvoli, F., Martin, C., Scienza, A., Gavazzi, G. & Tonelli, C. Plant Mol. Biol. 24, 743– 755 (1994).

    Article  CAS  Google Scholar 

  14. Raiber, S., Schröder, G. & Schröder, J. FEBS Lett. 361, 299–302 (1995).

    Article  CAS  Google Scholar 

  15. Schröder, J. et al. Biochemistry 37, 8417– 8425 (1998).

    Article  Google Scholar 

  16. Helariutta, Y. et al. Plant Mol. Biol. 28, 47– 60 (1995).

    Article  CAS  Google Scholar 

  17. Eckermann, S. et al. Nature 396, 387–390 (1998).

    Article  CAS  Google Scholar 

  18. Borejsza-Wysocki, W. & Hrazdina, G. Plant Physiol. 110, 791–799 ( 1996).

    Article  CAS  Google Scholar 

  19. Borejsza-Wysocki, W. & Hrazdina, G. Phytochemistry 35, 623–628 ( 1994).

    Article  CAS  Google Scholar 

  20. Ayabe, S.-I., Udagawa, A. & Furuya, T. Arch. Biochem. Biophys. 261, 458–462 (1988).

    Article  CAS  Google Scholar 

  21. Welle, R. & Grisebach, H. FEBS Lett. 236, 221–225 (1988).

    Article  CAS  Google Scholar 

  22. Welle, R., Schröder, G., Schiltz, E., Grisebach, H. & Schröder, J. Eur. J. Biochem. 196, 423–430 (1991).

    Article  CAS  Google Scholar 

  23. Zuurbier, K.W.M et al. Phytochemistry 49, 1945– 1951 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Institut für Biologie II, Universität Freiburg, Schänzlestrasse 1, Freiburg, D-79104, Germany

    Joachim Schröder

Authors
  1. Joachim Schröder
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schröder, J. Probing plant polyketide biosynthesis. Nat Struct Mol Biol 6, 714–716 (1999). https://doi.org/10.1038/11472

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/11472

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing