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Helping copper find a home

Nature Structural Biology volume 6, pages 709–711 (1999)Cite this article

Abstract

The crystal structure of the superoxide dismutase copper chaperone provides some key insights into the molecular mechanism of copper trafficking.

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Figure 1: Schematic representation of one possible model for copper transport.
Figure 2: The crystal structure of Atx1 complexed with mercury3.
Figure 3: This is a view of the yCCS dimer highlighting the expected location of the SOD metal ions (yellow balls) assuming that the yCCS–SOD heterodimer is basically the same as the yCCS and SOD dimers.

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Acknowledgements

I would like to thank T. O'Halloran and V. Culotta for valuable discussions and access to ref. 16 prior to publication, and A. Rosenzweig for atomic coordinates.

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  1. the Departments of Molecular Biology & Biochemistry and Physiology & Biophysics, and the Program in Macromolecular Structure, University of California at Irvine, Irvine, 926197-3900, California, USA

    Thomas L. Poulos

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Correspondence to Thomas L. Poulos.

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Poulos, T. Helping copper find a home. Nat Struct Mol Biol 6, 709–711 (1999). https://doi.org/10.1038/11464

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