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ReCoGnizing methylated DNA

Nature Structural Biology volume 8, pages 575–577 (2001)Cite this article

The solution structure of a 5-methyl CpG dinucleotide in complex with the methyl-CpG binding domain from human MBD1 has provided new insights into how dinucleotide sequences are specifically recognized. Surprisingly, the methyl groups of the symmetrically methylated CpG sequence are each recognized in a distinct manner.

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Figure 1: Solution structure of MBD1.
Figure 2: Alignment of MBD family members.

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Acknowledgements

P.W. is supported by grants from NICHD and the Rett Syndrome Research Foundation and gratefully acknowledges the Massachusetts Rett Syndrome Association for financial support.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, 30322, Georgia, USA

    Paul A. Wade & Alan P. Wolffe

  2. Sangamo BioSciences Incorporated, Richmond, 94804, California, USA

    Paul A. Wade & Alan P. Wolffe

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  1. Paul A. Wade
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  2. Alan P. Wolffe
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Correspondence to Paul A. Wade.

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Wade, P., Wolffe, A. ReCoGnizing methylated DNA. Nat Struct Mol Biol 8, 575–577 (2001). https://doi.org/10.1038/89593

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