Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Capturing the misfolds: chaperone-peptide-binding motifs

Recently, the crystal structure of the N-terminal fragment of human Hsp90-alpha chaperone and its complex with geldanamycin and the crystal structure of the N-terminal domain of yeast Hsp90 have been determined at high resolution. These structures reveal features that shed new light on the Hsp90 chaperone–protein interactions.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Gething, M-J. & Sambrook, J. Nature 355, 33–45 (1992).

    Article  CAS  Google Scholar 

  2. Fenton, W.A. & Horwich, A.L. Protein Sci. 6, 743–760 (1997).

    Article  CAS  Google Scholar 

  3. Martin, J. & Ultich-Hartl, F. Curr. Opin. Struct. Biol. 7, 41–52 (1997).

    Article  CAS  Google Scholar 

  4. Ruddon, R.W. & Bedows, E. J. Biol. Chem. 272, 3125–3128 (1997).

    Article  CAS  Google Scholar 

  5. Rutherford, S.L. & Zuker, C.S. Cell 79, 1129–1132 (1994).

    Article  CAS  Google Scholar 

  6. Braig, K. et al. Nature 371, 578–586 (1994).

    Article  CAS  Google Scholar 

  7. Buckle, A.M., Zahn, R. & Fersht, A.R. Proc. Natl. Acad. Sci. USA 94, 3571–3575 (1997).

    Article  CAS  Google Scholar 

  8. Flaherty, K.M., DeLuca-Flaherty, C. & McKay, D.B. Nature 346, 623–628 (1990).

    Article  CAS  Google Scholar 

  9. Sriram, M., Osipiuk, J., Freeman, B.C., Morimoto, R.I. & Joachimiak, A. Structure 5, 403–414 (1997).

    Article  CAS  Google Scholar 

  10. Zhu, X. et al. Science 272, 1606–1614 (1996).

    Article  CAS  Google Scholar 

  11. Jakob, U. & Buchner, J. TIBS 19, 205–211 (1994).

    CAS  PubMed  Google Scholar 

  12. Bose, S., Weike, T., Bügl, H. & Buchner, J. Science 274, 1715–1717 (1996).

    Article  CAS  Google Scholar 

  13. Freeman, B.C., Toft, D.O. & Morimoto, R.I. Science 274, 1718–1720 (1996).

    Article  CAS  Google Scholar 

  14. Freeman, B.C. & Morimoto, R.I. EMBO J. 15, 2969–2979 (1996).

    Article  CAS  Google Scholar 

  15. Yonehara, M., Minami, Y., Kawata, Y., Nagai, J. & Yahara I. J. Biol. Chem. 271, 2641–2645 (1996).

    Article  CAS  Google Scholar 

  16. Bohen, S.P. & Yamamoto, K.R. The Biology of Heat Shock Proteins and Molecular Chaperones (eds Morimoto, R.I., Tissières, A. & Georgopoulos, C.) 313–334 (Cold Spring Harbor Laboratory Press, New York, 1994).

    Google Scholar 

  17. Whitesell, L., Mimnaugh, E.G., De Costa, B., Myers, C.E. & Neckers, L.M. Proc. Natl. Acad. Sci. USA 91, 8324–8328 (1994).

    Article  CAS  Google Scholar 

  18. Smith, D.F. et al. Mol. Cell Biol. 15, 6804–6812 (1995).

    Article  CAS  Google Scholar 

  19. Schneider, C., Sepp-Lorenzino, L., Nimmesgern, E., Ouerfelli, O., Danishefsky, S., Rosen, N. & Ulrich-Hartl, F. Proc Natl. Acad. Sci. USA 93, 14536–14541 (1996).

    Article  CAS  Google Scholar 

  20. Bohen, S.P. & Yamamoto, K.R. Proc. Natl. Acad. Sci. USA 90, 11424–11428 (1993).

    Article  CAS  Google Scholar 

  21. Cadepond, F et.al. Proc. Natl. Acad. Sci. USA 90, 10434–10438 (1993).

    Article  CAS  Google Scholar 

  22. Jakob, U., Meyer, I., Bügl, H., André, S., Bardwell, J.C.A. & Buchner, J. J. Biol. Chem. 270, 14412–14419 (1995).

    Article  CAS  Google Scholar 

  23. Jakob, U., Scheibel, T., Bose, S., Reinstein, J. & Buchner, J. J. Biol. Chem. 271, 10035–10041 (1996).

    Article  CAS  Google Scholar 

  24. Wearsch, P.A. & Nicchitta, C.V. J. Biol. Chem. 272, 5152–5156 (1997).

    Article  CAS  Google Scholar 

  25. Sullivan, W. et al. J. Biol. Chem. 272, 8007–8012 (1997).

    Article  CAS  Google Scholar 

  26. Stebbins, C.E., Russo, A.A., Schneider, C., Rosen, N., Ulrigh-Hartl, F. & Pavletich, N.P. Cell 89, 239–250 (1997).

    Article  CAS  Google Scholar 

  27. Prodromou, C., Roe, S.M., Piper, P.W. & Pearl, L.H. Nature Structural Biol. 477–482 (1997).

  28. Owens-Grillo, J.K., Stancato, L.F., Hoffmann, I., Pratt, W.B. & Krishna, P. Biochemistry 35, 15249–15255 (1996).

    Article  CAS  Google Scholar 

  29. Nieland, T.J.F. et al. Proc. Natl. Acad. Sci. USA 93, 6135–6139 (1996).

    Article  CAS  Google Scholar 

  30. Fremont, D.H., Stura, E.A., Matsumura, M., Peterson, P.A. & Wilson, I.A. Proc. Nat. Acad. Sci. USA 92, 2479 (1995).

    Article  CAS  Google Scholar 

  31. Stanfield, R.L. & Wilson, I.A. Curr. Opinion Structural Biol. 5, 103–113 (1995).

    Article  CAS  Google Scholar 

  32. Tame, J.R.H. et al. Science 264, 1578–1581 (1994).

    Article  CAS  Google Scholar 

  33. Fenton, W.A., Kashi, Y., Furtak, K. & Norwich, A.L. Nature 371, 614–619 (1994).

    Article  CAS  Google Scholar 

  34. Keuhn, M.J. et al. Science 262, 1234–1241 (1993).

    Article  Google Scholar 

  35. Madden, D.R., Gorga, J.C., Strominger, J.L. & Wiley, D.C. Cell 70, 1035–1048 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Joachimiak, A. Capturing the misfolds: chaperone-peptide-binding motifs. Nat Struct Mol Biol 4, 430–434 (1997). https://doi.org/10.1038/nsb0697-430

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0697-430

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing