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RNA is all you need

Crystallographic, biochemical and computational studies of the hairpin ribozyme define its structure and reveal likely components of an enzyme active site that is comprised entirely of ribonucleotides.

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Figure 1: Stereo view of the global structure of the hairpin ribozyme in a complex with a noncleavable substrate analog and U1A protein.
Figure 2: Stereo view of the structure at the active site.

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Burke, J. RNA is all you need. Nat Struct Mol Biol 8, 382–384 (2001). https://doi.org/10.1038/87527

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