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Two insulators are not better than one

Nature Structural Biology volume 8, pages 192–194 (2001)Cite this article

Chromatin insulators seem to control eukaryotic gene expression by regulating interactions between enhancers and promoters. Mounting evidence suggests that these sequences play a complex role in the regulation of transcription, perhaps mediated by changes in chromatin structure and nuclear organization.

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Figure 1: Effects of insulators on enhancer–promoter interactions.
Figure 2: Formation of loop domains by an insulator.

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  1. the Department of Biology, The Johns Hopkins University, 3400 N. Charles St., Baltimore, 21218, Maryland, USA

    Fabien Mongelard & Victor G. Corces

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  1. Fabien Mongelard
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  2. Victor G. Corces
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Correspondence to Victor G. Corces.

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Mongelard, F., Corces, V. Two insulators are not better than one. Nat Struct Mol Biol 8, 192–194 (2001). https://doi.org/10.1038/84905

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