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The taming of the SNARE

The structures of two syntaxin homologs, Sso1p and Vam3p, reveal two different conformations. The contrast between these structures suggests alternative modes of regulation for membrane fusion at different sites in the cell.

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Figure 1: A model for the mechanism of SNARE complex assembly.
Figure 2: Stability hotspots in Sso1p and sites of interaction between Syntaxin 1A and nSec1.
Figure 3: Comparison of the Habc domains of Syntaxin 1A, Sso1p and Vam3p.
Figure 4: Conformations of Syntaxin 1A, Sso1p and Vam3p.

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Carr, C. The taming of the SNARE. Nat Struct Mol Biol 8, 186–188 (2001). https://doi.org/10.1038/84895

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