High resolution structures of the Tet and Lac repressors bound to their respective operator DNA sites provide endpoints for the functional allosteric pathways in these distinct regulatory systems.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Design and application of a lactulose biosensor
Scientific Reports Open Access 07 April 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Orth, P. et al. Nature Struct. Biol. 7, 215– 219 (2000).
Bell, C. E. & Lewis, M. Nature Struct. Biol. 7 , 209–214 (2000).
Jacob, F. & Monod, J. J. Mol. Biol. 3, 318–356 (1961).
Gilbert, W. & Müller-Hill, B. Proc. Natl. Acad. Sci. USA 56, 1891–1898 ( 1966).
Matthews, K. S. & Nichols, J.C. Prog. Nucl. Acid Res. Mol. Biol. 58, 127–164 (1998).
Hillen, W. & Berens, C. Annu. Rev. Microbiol. 48, 345–369 (1994).
Gossen, M. et al. Science 268, 1766–1769 (1995).
Freundlieb, S. et al. Meth. Enzymol. 283, 159– 173 (1997).
Hinrichs, W. et al. Science 264, 418–420 (1994).
Kisker, C. et al. J. Mol. Biol. 247, 260– 280 (1995).
Orth, P. et al. J. Mol. Biol. 279, 439– 447 (1998).
Chuprina, V.P. et al. J. Mol. Biol. 234, 446– 462 (1993).
Lewis, M. et al. Science, 271, 1247–1254 (1996).
Spronk, C.A.E.M. et al. Nature Struc. Biol. 3, 916– 919 (1996).
Lederer, T., Takahashi, M. & Hillen, W. Anal.Biochem. 232, 190– 196 (1995).
Weickert, M. J. & Adhya, S. J. Biol. Chem. 267, 15869–15874 (1992).
Schumacher, M.A. et al. Cell 83, 147–155 (1995).
Schumacher, M.A., Choi, K.Y., Zalkin, H. & Brennan, R.G. Science 266, 763–770 (1994).
Otwinowski, Z. et al. Nature 335, 321–329 (1988).
Phillips, K. & Phillips, S.E.V. Structure 2, 309–316 (1994).
Soisson, S. M., MacDougall-Shackleton, B., Schleif, R. & Wolberger, C. Science 276, 421–425 ( 1997).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Matthews, K., Falcon, C. & Swint-Kruse, L. Relieving repression. Nat Struct Mol Biol 7, 184–187 (2000). https://doi.org/10.1038/73274
Issue Date:
DOI: https://doi.org/10.1038/73274
This article is cited by
-
Design and application of a lactulose biosensor
Scientific Reports (2017)