Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Relieving repression

High resolution structures of the Tet and Lac repressors bound to their respective operator DNA sites provide endpoints for the functional allosteric pathways in these distinct regulatory systems.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The TetR and LacI operons.
Figure 2: More detailed description of the motions that are elicited by the binding of inducers.

References

  1. Orth, P. et al. Nature Struct. Biol. 7, 215– 219 (2000).

    Article  CAS  Google Scholar 

  2. Bell, C. E. & Lewis, M. Nature Struct. Biol. 7 , 209–214 (2000).

    Article  CAS  Google Scholar 

  3. Jacob, F. & Monod, J. J. Mol. Biol. 3, 318–356 (1961).

    Article  CAS  Google Scholar 

  4. Gilbert, W. & Müller-Hill, B. Proc. Natl. Acad. Sci. USA 56, 1891–1898 ( 1966).

    Article  CAS  Google Scholar 

  5. Matthews, K. S. & Nichols, J.C. Prog. Nucl. Acid Res. Mol. Biol. 58, 127–164 (1998).

    Article  CAS  Google Scholar 

  6. Hillen, W. & Berens, C. Annu. Rev. Microbiol. 48, 345–369 (1994).

    Article  CAS  Google Scholar 

  7. Gossen, M. et al. Science 268, 1766–1769 (1995).

    Article  CAS  Google Scholar 

  8. Freundlieb, S. et al. Meth. Enzymol. 283, 159– 173 (1997).

    Article  CAS  Google Scholar 

  9. Hinrichs, W. et al. Science 264, 418–420 (1994).

    Article  CAS  Google Scholar 

  10. Kisker, C. et al. J. Mol. Biol. 247, 260– 280 (1995).

    Article  CAS  Google Scholar 

  11. Orth, P. et al. J. Mol. Biol. 279, 439– 447 (1998).

    Article  CAS  Google Scholar 

  12. Chuprina, V.P. et al. J. Mol. Biol. 234, 446– 462 (1993).

    Article  CAS  Google Scholar 

  13. Lewis, M. et al. Science, 271, 1247–1254 (1996).

    Article  CAS  Google Scholar 

  14. Spronk, C.A.E.M. et al. Nature Struc. Biol. 3, 916– 919 (1996).

    Article  CAS  Google Scholar 

  15. Lederer, T., Takahashi, M. & Hillen, W. Anal.Biochem. 232, 190– 196 (1995).

    Article  CAS  Google Scholar 

  16. Weickert, M. J. & Adhya, S. J. Biol. Chem. 267, 15869–15874 (1992).

    CAS  PubMed  Google Scholar 

  17. Schumacher, M.A. et al. Cell 83, 147–155 (1995).

    Article  CAS  Google Scholar 

  18. Schumacher, M.A., Choi, K.Y., Zalkin, H. & Brennan, R.G. Science 266, 763–770 (1994).

    Article  CAS  Google Scholar 

  19. Otwinowski, Z. et al. Nature 335, 321–329 (1988).

    Article  CAS  Google Scholar 

  20. Phillips, K. & Phillips, S.E.V. Structure 2, 309–316 (1994).

    Article  CAS  Google Scholar 

  21. Soisson, S. M., MacDougall-Shackleton, B., Schleif, R. & Wolberger, C. Science 276, 421–425 ( 1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kathleen S. Matthews.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matthews, K., Falcon, C. & Swint-Kruse, L. Relieving repression. Nat Struct Mol Biol 7, 184–187 (2000). https://doi.org/10.1038/73274

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/73274

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing