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Antigen distortion allows influenza virus to escape neutralization

Nature Structural Biology volume 5, pages 119–123 (1998)Cite this article

Abstract

The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA·Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.

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Authors and Affiliations

  1. Laboratoire d'Enzymologie et Biochimie Structurales, (UPR 9063 CNRS), Bǎt. 34, CNRS, 91198, Gif-sur-Yvette Cedex, France

    Damien Fleury, Marcel Knossow & Thierry Bizebard

  2. National Institute for Medical Research, Mill Hill, London, NW7 1AA, U.K.

    Steve A. Wharton & John J. Skehel

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  1. Damien Fleury
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  2. Steve A. Wharton
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  4. Marcel Knossow
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  5. Thierry Bizebard
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Fleury, D., Wharton, S., Skehel, J. et al. Antigen distortion allows influenza virus to escape neutralization. Nat Struct Mol Biol 5, 119–123 (1998). https://doi.org/10.1038/nsb0298-119

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