The structure of the catalytic domain of HIV integrase reveals a similarity with other proteins involved in DNA recombination or RNA degradation. Knowledge of the structure may help in the search for inhibitors of HIV replication.
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References
Dyda, F. et al. Science 266, 1981–1986 (1994).
Mizuuchi, K. & Craigie, R. A. Rev. Genet. 20, 385–429 (1986).
Mizuuchi, K. A. Rev. Biochemistry 61, 1011–1051 (1992).
Engelman, A., Mizuuchi, K. & Craigie, R. Cell 67, 1211–1221 (1991).
Duyk, G., Leis, J., Longiaru, M. & Skalka, A.M. Proc. natn. Acad. Sci. U.S.A. 80, 6745–6749 (1983).
Schiff, R.D. & Grandgenett, D.P. J. Virol. 28, 279–291 (1978).
Murphy, J.E. & Goff, S.P. J. Virol. 66, 5092–5095 (1992).
Vink, C., Van Gent, D., Elgersma, Y. & Plasterk, R.H.A. J. Virol. 65, 4636–4644 (1991).
Vink, C. & Plasterk, R.H.A. Trends Genet. 9, 433–4137 (1993).
Fayet, O., Ramond, P., Polard, P., Prere, M.F. & Chandler, M. Molec. Microbiol. 4, 1771–1777 (1990).
Kulkosky, J., Jones, K.S., Katz, R.A., Mack, J.P.G. & Skalka, A.M. Molec. cell. Biol. 12, 2331–2338 (1992).
Van Gent, D.C., Vink, C., Oude Groeneger, A.A.M. & Plasterk, R.H.A. EMBO J. 12, 3261–3267 (1993).
Engelman, A., Bushman, F.D. & Craigie, R. EMBO J. 12, 3269–3275 (1993).
Chow, S.A., Vincent, K.A., Ellison, V. & Brown, P.O. Science 255, 723–726 (1992).
Ariyoshi, M., Vassylyev, D.G., Iwasaki, H., Nakamura, H., Shinagawa, H. & Morikawa, K. Cell 76, 1063–1072.
West, S. Cell 76, 9–15 (1994).
Yang, W., Hendrickson, W.A., Crouch, R.J., Satow, W. Science 249, 1398–1405 (1990).
Orengo, C.A., Jones, D.T. & Thornton, J.M. Nature 372, 632–634 (1994).
Baker, T.A., Mizuuchi, M., Savilahti, H. & Mizuuchi, K. Cell 74, 723–733 (1993).
Lee, Y.M. & Coffin, J.M. J. Virol. 64, 5958–5965 (1990).
Soo Lee, M. & Craigie, R. Proc. natn. Acad. Sci. U.S.A. 91, 9823–9827 (1994).
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Plasterk, R. The HIV integrase catalytic core. Nat Struct Mol Biol 2, 87–90 (1995). https://doi.org/10.1038/nsb0295-87
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DOI: https://doi.org/10.1038/nsb0295-87
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