Men with node-positive (N1) prostate cancer have good outcomes with surgery and external beam radiation therapy (EBRT), but N1 cancer can behave in different ways. A matched case analysis of men with pN1 prostate cancer versus pN0 patients (n = 69 per group) treated with EBRT with androgen deprivation showed no difference in recurrence-free survival between the groups; 5-year prostate-cancer-specific survival and overall survival were also similar, and toxic effects were rare. Primary EBRT + ADT represents a reasonable treatment option for men with pN1 prostate cancer.
References
Van Hemelryk, A. et al. The outcome for pathological node positive prostate cancer patients treated with intensity-modulated radiotherapy and androgen deprivation therapy: a case-matched analysis of pN1 and pN0 patients. Int. J. Radiat. Oncol. Biol. Phys. http://dx.doi.org/10.1016/j.ijrobp.2016.06.011 (2016)
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Fenner, A. EBRT + ADT outcomes for node-positive patients. Nat Rev Urol 13, 437 (2016). https://doi.org/10.1038/nrurol.2016.120
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DOI: https://doi.org/10.1038/nrurol.2016.120
