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Kidney cancer

Finding a niche for girentuximab in metastatic renal cell carcinoma

For nearly two decades, carbonic anhydrase IX (CAIX) expression has been investigated as a prognostic marker in renal cell carcinoma (RCC). During this time, CAIX-directed treatments have emerged, including 177Lu-labelled girentuximab. A small phase II study highlights modest efficacy and a concerning safety profile associated with this compound in patients with metastatic RCC.

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Correspondence to Sumanta K. Pal.

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S.K.P. receives honoraria from Astellas, Medivation and Novartis, and receives consulting fees from Astellas, Aveo, BMS, Exelixis, Genentech, GSK, Novartis and Pfizer. N.A. declares no competing interests.

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Pal, S., Agarwal, N. Finding a niche for girentuximab in metastatic renal cell carcinoma. Nat Rev Urol 13, 442–443 (2016). https://doi.org/10.1038/nrurol.2016.115

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